Dr. Stephen Phinney: Does a ketogenic diet improve fatty liver disease?

This is really exciting. There’s a really cool article theother era – maybe it was a few weeks ago – that came out in Cell Metabolism. And the thing that I really like about Cell Metabolism is that they “theyre trying to” do the translational experiment between looking at mechanisms and too “ve got something” verypractical in humen. So they made a group of people with fatty liver and they leant them on a ketogenic diet. And they found some really interesting things over term. So they are did this for two weeks so very different in scale in terms of what we are doing with our inquiry. But they generated the person or persons and they did all of their baseline measurings on them and in one day they investigated significant reduction in fatty material in the liver. And I think it was reduced by almost half after fourteen epoches at the end.And then exactly to made to ensure that the ketogenic nutrition was the move behind that change in their liver solid content. After the person or persons culminated the study and they went back to consumingtheir normal diet they returned ten of their subjects back in one to three months later and quantity their liver fatten material again, and heard the group returned almost back up to baseline. In just that one to three monthsafter they had completed the involvement. So I think this is really interesting and it’s showing a lot of promise in terms of different ways that we can use nutrition to treat fatty liver. And you know if we’re not if we can cut down some of the fat material and explore some of these mechanisms I think it’s going to be a reallyinteresting study expanse. This is a real paradox because again as I said before there is this common myth that you are what you eat.And beings presuppose well if you devour a high overweight nutrition then all that paunches going to go through your digestive method, and be brought to an end in your liver, but that’s not what happens. Sure. The liver becomes very efficient at clearing the fatty. Some of it is uttered into ketones maybe as much as 100 g of fatty is done in the ketones by the liver each day, when someone is on thewell-formulated ketogenic nutrition. So the liver is not the place where the fatty goes to hide or reside, when you are keto-adapted. And there’s more experiment being done on that. My co-author and technical traitor and very good friend Dr.Jeff Volek at Ohio State University is doing some very precise imaging studies on people on the ketogenic died over a three month period of time, and that study would hopefully been issued last-minute this year. And we’re looking at that more sophisticated biomarkers in our Lafayette research study and hopefully well we’ll be publishing that data shortly as well. Yeah this study did a really nice look at some of the underlying mechanisms are demonstrating that De Novo lipogensis was actually retarded, they established the increased rate ofketone protection. So they are showing that betaoxidation charges were going up. So they did a really nice, I meditate stylish, job of present some of those very early conversions even before modification followed potentially because they were seeing those changes and 3, 5, 7 days. And stepping back a little only up until four or five years ago there were very few people doing research. Well done research on ketogenic diets. In happening, live was kind of lonely back then and we’re understand more and more really top notch experiment radicals getting engaged in this area.And I foresee( A) it’s it’s good to have very best thoughts looking at this and you know and again our job is not to prove we’re right but you know find out where we’re wrong and correct those things. And it’sreally great to see other parties coming in who, you know, aren’t considered advocates in this area doing high quality research, such as this recent article inCell Metabolism ..


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